Mayo was born in Fresno, California, and began their acting career appearing in the local stage productions and at their high school Roosevelt School of the Arts. She relocated to Los Angeles and began a modeling career before making her television debut. In 2011, Mayo guest starred in an episode of the short-lived NBC police series, Law & Order: LA.
In 2013, they had a recurring role in the BET comedy series The Game, and the following year joined the cast of Days of Our Lives as Zoe Browning. She appeared on the show on a recurring basis from August 2014 to July 2015. In early 2015, Mayo had the recurring role as Talia Sandoval during the fifth season of the ABC Family teen drama series Pretty Little Liars.
In the same year, she also appeared in the second season of HBO anthology crime series True Detective, and was cast in the recurring role of the Showtime drama series The Affair as Joshua Jackson's character's new love interest, but due to her Blood & Oil contractual obligations, she left The Affair. In 2016, she joined the cast of Chicago Fire playing Stella Kidd, the new firefighter.
Notes and Trivia
- Mayo's height is 5'9" (1.78 m).
- Twitter Of Miranda Rae Mayo: 
- Her western zodiac sign is Leo and her Chinese zodiac sign is a Horse.